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Invitrogen
CTLA-4 (CD152) (Biosimilar) Recombinant Humanized mouse Monoclonal Antibody
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产品信息
MA5-59919
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Artificial Control
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term Antitope patent anti-CTLA4.
靶标信息
CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor expressed on mainly CD4+ T cells. It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells), but with higher affinity than CD28. However, in contrast to CD28 which enhances cell function when bound at the same time as the T cell receptor, CTLA4 inhbits the T cell and prevents it from functioning. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD152; CD152 isoform; celiac disease 3; costimulatory receptor; CTLA-4; costimulatory receptor; ss-CD152; CTLA-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated protein 4; cytotoxic T-lymphocyte-associated serine esterase-4; gluten-sensitive enteropathy; ICOS; insulin-dependent diabetes mellitus 12; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; putative B7 binding protein; unnamed protein product
基因别名: ALPS5; CD; CD152; CELIAC3; CTLA-4; CTLA4; GRD4; GSE; IDDM12
UniProt ID: (Human) P16410
Entrez Gene ID: (Human) 1493
adaptive immune response
immune system process
immune response
cellular response to DNA damage stimulus
negative regulation of B cell proliferation
regulation of T cell proliferation
negative regulation of T cell proliferation
positive regulation of apoptotic process
negative regulation of regulatory T cell differentiation
T cell receptor signaling pathway
B cell receptor signaling pathway
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