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Leinco Technologies
CTLA-4 (Ipilimumab) Recombinant Human Monoclonal Antibody (MDX-010), Functional Grade, Fc Muted™
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产品信息
LT1605-500UG
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Human
/ IgG1, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
MDX-010
抗原
Human CTLA-4
偶联物
Functional Grade
Functional Grade
Functional Grade
形式
Liquid
浓度
≥5.0 mg/mL
规格
500 µg
保存条件
4°C short term, -80°C long term
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Specificity: This non-therapeutic biosimilar antibody uses the same variable region sequence as the therapeutic antibody Ipilimumab. Ipilimumab binds to Human CTLA-4.
Endotoxin Level: <1.0 EU/mg as determined by the LAL method.
Purity: ≥95% monomer by analytical SEC.
Preparation: Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Pathogen Testing: To protect mouse colonies from infection by pathogens and to assure that experimental preclinical data is not affected by such pathogens, all of Leinco recombinant biosimilar antibodies are tested and guaranteed to be negative for all pathogens in the IDEXX IMPACT I Mouse Profile.
Storage: Functional grade biosimilar antibodies may be stored sterile as received at 2-8C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80C. Avoid Repeated Freeze Thaw Cycles.
靶标信息
CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor expressed on mainly CD4+ T cells. It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells), but with higher affinity than CD28. However, in contrast to CD28 which enhances cell function when bound at the same time as the T cell receptor, CTLA4 inhbits the T cell and prevents it from functioning. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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