Abnova

CUL2 Recombinant Rabbit Monoclonal Antibody

Name: CUL2 Recombinant Rabbit Monoclonal Antibody
Brand: Abnova
SKU: RAB02356

查看其他11个Cullin 2抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (1)

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CUL2 Antibody (RAB02356) in WB

Western Blot analysis of Lane 1: K562, Lane 2: C6, Lane 3: 3T3 and Lane 4: Hela lysates with CUL2 recombinant monoclonal antibody, clone R09-8A9 (Product # RAB02356).

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产品信息

RAB02356

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫沉淀 (IP)

1:20

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

CHO cells

分类

Recombinant Monoclonal

类型

Antibody

抗原

Synthetic peptide corresponding to human CUL2.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

纯化类型

Affinity chromatography

保存液

50mM tris glycine, pH 7.4, with 150mM NaCl, 0.05% BSA, 40% glycerol

内含物

0.01% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_3710907

靶标信息

Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). [UniProt]

仅用于科研。不用于诊断过程。未经明确授权不得转售。