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Abnova
CUL3 Monoclonal Antibody (1A3)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00008452-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
1A3
抗原
CUL3 (AAH39598, 301 a.a. approximately 400 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: KLFSRVPNGL KTMCECMSSY LREQGKALVS EEGEGKNPVD YIQGLLDLKS RFDRFLLESF NNDRLFKQTI AGDFEYFLNL NSRSPEYLSL FIDDKLKKGV
靶标信息
Cullin 3 is a member of the family of human cullin genes (CUL 1, 2, 3, 4a, 4b, and 5) homologous to the S. cerevisiae cdc 53 gene. CUL 1 forms a complex with human p19 skp1 and F box protein p45 skp2. Together with cdc 53 (Known as Cul A), as three subunits, they form a ubiquitin ligase-controlling proteolysis of G1 cell cycle regulatory proteins. In contrast to CUL 1, CUL 2 does not associate with p19 skp1 and p45 skp2. Instead, CUL 2 forms a complex with an inactive transcriptional elongation complex, SIII, formed by three subunits: Elongain C, Elongin B and VHL. The function of this association remains unknown.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CUL-3; OTTHUMP00000203839; OTTHUMP00000203840; unnamed protein product
基因别名: CUL-3; NEDAUS; PHA2E
UniProt ID: (Human) Q13618
Entrez Gene ID: (Human) 8452
G1/S transition of mitotic cell cycle
protein polyubiquitination
mitotic cell cycle
kidney development
ubiquitin-dependent protein catabolic process
protein monoubiquitination
ER to Golgi vesicle-mediated transport
apoptotic process
response to stress
inflammatory response
mitotic metaphase plate congression
signal transduction
integrin-mediated signaling pathway
positive regulation of cell proliferation
gene expression
regulation of gene expression
cell migration
protein ubiquitination
stem cell division
protein catabolic process
anaphase-promoting complex-dependent catabolic process
positive regulation of protein ubiquitination
protein destabilization
positive regulation of cytokinesis
negative regulation of type I interferon production
cellular response to oxidative stress
negative regulation of Rho protein signal transduction
embryonic cleavage
stress fiber assembly
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of cilium assembly
positive regulation of mitotic metaphase/anaphase transition
COPII vesicle coating
protein autoubiquitination
establishment of endothelial barrier
protein K48-linked ubiquitination
cellular response to amino acid stimulus
nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
intrinsic apoptotic signaling pathway
regulation protein catabolic process at postsynapse
regulation of cellular response to insulin stimulus
positive regulation of mitotic cell cycle phase transition
positive regulation of protein K63-linked ubiquitination
positive regulation of TORC1 signaling
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