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Invitrogen
CWC22 Polyclonal Antibody
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CWC22 Antibody (PA5-24276) in IHC (P)
Immunohistochemistry analysis of CWC22 in formalin fixed and paraffin embedded human brain tissue. Samples were incubated with CWC22 polyclonal antibody (Product # PA5-24276) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
产品信息
PA5-24276
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human CWC22
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Required for pre-mRNA splicing as component of the spliceosome (PubMed:12226669, PubMed:11991638, PubMed:22961380, PubMed:28502770, PubMed:28076346, PubMed:29360106, PubMed:29301961). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CWC22 spliceosome-associated protein homolog; fSAPb; functional spliceosome-associated protein b; Nucampholin homolog; Pre-mRNA-splicing factor CWC22 homolog
基因别名: CWC22; EIF4GL; fSAPb; KIAA1604; NCM
UniProt ID: (Human) Q9HCG8
Entrez Gene ID: (Human) 57703
