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Proteintech
CX3CL1 Polyclonal Antibody
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产品信息
32529-1-AP
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein
偶联物
形式
Liquid
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Sequence of this protein is as follows: TKCNITCHKM TSPIPVTLLI HYQLNQESCG KRAIILETRQ HRHFCADPKE KWVQDAMKHL DHQTAALTRN GGKFEKRVDN VTPRITSATR GLSPTALAKP ESATVEDLTL EPTAISQEAR RPMGTSQEPP AAVTGSSPST SKAQDAGLAA KPQSTGISEV AAVSTTIWPS SAVYQSGSSL WAEEKATESP PTIALSTQAS TTSSPKQNVG SEGQPPWVQE QDSTPEKSPG PEETNPVHTD IFQDRGPGST VHPSVAPTSS EKTPSPELVA SGSQAPKVEE PIHATADPQK LSVFITPVPD SQAATR
靶标信息
Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-a in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ABCD-3; C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; FK; Fractalkine; Neurotactin; small inducible cytokine subfamily D, 1; Small-inducible cytokine D1
基因别名: AB030188; ABCD-3; Acc1; AI848747; CX3C; Cx3cl1; Cxc3; D8Bwg0439e; Fkn; Scyd1
UniProt ID: (Rat) O55145, (Mouse) O35188
Entrez Gene ID: (Rat) 89808, (Mouse) 20312
response to hypoxia
microglial cell activation
positive regulation of neuroblast proliferation
chemotaxis
immune response
cell adhesion
aging
positive regulation of macrophage chemotaxis
cytokine-mediated signaling pathway
platelet activation
positive regulation of cell migration
neutrophil chemotaxis
positive regulation of transforming growth factor beta1 production
wound healing
positive regulation of angiogenesis
positive regulation of cell adhesion
negative regulation of vasoconstriction
macrophage chemotaxis
lymphocyte chemotaxis
positive regulation of smooth muscle cell proliferation
negative regulation of cytokine secretion
positive regulation of inflammatory response
positive regulation of calcium-independent cell-cell adhesion
angiogenesis involved in wound healing
inhibitory postsynaptic potential
cell chemotaxis
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
leukocyte adhesive activation
