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Invitrogen
CX3CL1 Polyclonal Antibody
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CX3CL1 Antibody (PA5-47728) in IHC (F)
Immunohistochemical analysis of CX3CL1 in perfusion fixed frozen sections of mouse brain (cingulate cortex). Samples were incubated in CX3CL1 polyclonal antibody (Product # PA5-47728) using a dilution of 1.7 µg/mL overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue).
产品信息
PA5-47728
应用
建议稀释比
已发表文章
产品规格
种属反应
Rat
已发表种属
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant rat CX3CL1/Fractalkine Gln25-Gly100
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In Western blots, less than 5% cross-reactivity with recombinant human (rh) Eotaxin is observed. This antibody neutralizes the biological activity of rhCX3CL1 and rmCX3CL1 with similar effectiveness.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
靶标信息
Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-a in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Fractalkine; Neurotactin; small inducible cytokine subfamily D, 1; Small-inducible cytokine D1
基因别名: Acc1; Cx3c; Cx3cl1; Fkn; Scyd1
UniProt ID: (Rat) O55145
Entrez Gene ID: (Rat) 89808
response to hypoxia
microglial cell activation
positive regulation of neuroblast proliferation
chemotaxis
immune response
cell adhesion
aging
positive regulation of macrophage chemotaxis
cytokine-mediated signaling pathway
platelet activation
positive regulation of cell migration
neutrophil chemotaxis
positive regulation of transforming growth factor beta1 production
wound healing
positive regulation of angiogenesis
positive regulation of cell adhesion
negative regulation of vasoconstriction
macrophage chemotaxis
lymphocyte chemotaxis
positive regulation of smooth muscle cell proliferation
negative regulation of cytokine secretion
positive regulation of inflammatory response
positive regulation of calcium-independent cell-cell adhesion
angiogenesis involved in wound healing
inhibitory postsynaptic potential
cell chemotaxis
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
