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Alomone Labs, LTD
CaV1.3 (CACNA1D) (extracellular) Polyclonal Antibody, FITC
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CaV1.3 (CACNA1D) (extracellular) Antibody (ACC-311-F-50UL) in Flow
Cell surface detection of Ca V 1.3 by direct flow cytometry in live intact human Jurkat T-cell leukemia cell line. Black line: Cells. Red line: Cells + Rabbit IgG Isotype Control-FITC (#RIC-001-F). Green line: Cells + Anti-Ca V 1.3 (CACNA1D) (extracellular)-FITC Antibody (#ACC-311-F) (5 µg).
产品信息
ACC-311-F-50UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide DSMLHGTGMKSDLDQK, corresponding to amino acid residues 27-42 of mouse BMPR1A. Extracellular, N-terminus.
偶联物
FITC
FITC
FITC
激发/发射光谱
498/517 nm
查看光谱
形式
Lyophilized
浓度
1 mg/mL
规格
50 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles, store in dark
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunogen sequence: DSMLHGTGMKSDLDQK
Reconstitution: 25 uL, 50 uL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
CACNA1D is also known as PASNA, SANDD or Cav1. 3. Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: brain class D; CACNA 1D; calcium channel alpha-1 subunit; calcium channel, L type, alpha-1 polypeptide; Calcium channel, L type, alpha-1 polypeptide isoform 2; Calcium channel, L type, alpha-1 polypeptide, isoform 2; calcium channel, neuroendocrine/brain-type, alpha 1 subunit; calcium channel, voltage-dependent, L type, alpha 1D subunit; CaV1.3alpha1; RBD; unnamed protein product; voltage-dependent calcium channel subunit alpha1D; Voltage-dependent L-type calcium channel subunit alpha-1D; voltage-gated calcium channel alpha 1 subunit; voltage-gated calcium channel alpha subunit Cav1.3; voltage-gated calcium channel pore forming subunit CaV1.3alpha1 IVS3-IVS4 extracellular linker; Voltage-gated calcium channel subunit alpha Cav1.3
基因别名: 8430418G19Rik; C79217; CACH3; CACN4; CACNA1D; CACNL1A2; Cav1.3; Cchl1a; CCHL1A2; D-LTCC; PASNA; SANDD
UniProt ID: (Human) Q01668, (Mouse) Q99246
Entrez Gene ID: (Human) 776, (Mouse) 12289, (Rat) 29716
ion channel activity
voltage-gated calcium channel activity
calcium channel activity
protein binding
cytoskeletal protein binding
high voltage-gated calcium channel activity
ankyrin binding
metal ion binding
alpha-actinin binding
voltage-gated calcium channel activity involved in cardiac muscle cell action potential
voltage-gated calcium channel activity involved SA node cell action potential
PDZ domain binding
voltage-gated ion channel
ion transport
calcium ion transport
muscle contraction
cell communication
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
sensory perception of sound
regulation of metal ion transport
signaling
ion transmembrane transport
positive regulation of adenylate cyclase activity
neurological system process
positive regulation of transport
positive regulation of calcium ion transport
transmembrane transport
regulation of atrial cardiac muscle cell membrane repolarization
calcium ion import
calcium ion transmembrane transport
cardiac muscle cell action potential involved in contraction
membrane depolarization during cardiac muscle cell action potential
membrane depolarization during SA node cell action potential
regulation of heart rate by cardiac conduction
calcium ion import across plasma membrane
regulation of potassium ion transmembrane transport
heart development
aging
memory
calcium-mediated signaling
positive regulation of CREB transcription factor activity
regulation of ion transmembrane transport
regulation of calcium ion transport
divalent metal ion transport
membrane depolarization during action potential
membrane repolarization during SA node cell action potential
regulation of potassium ion transmembrane transporter activity
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