Invitrogen

Carboxypeptidase A1/B1/A2 Recombinant Rabbit Monoclonal Antibody (K01_4K18)

Name: Carboxypeptidase A1\/B1\/A2 Recombinant Rabbit Monoclonal Antibody (K01_4K18)
Brand: Invitrogen
SKU: MA567246

说明书

证书

实验方案

问题与答案

技术支持

说明书

证书

实验方案

问题与答案

技术支持

说明书

证书

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (1)

Carboxypeptidase A1/B1/A2 Antibody in Western Blot (WB)

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Carboxypeptidase A1/B1/A2 Antibody (MA567246) in WB

Western Blot analysis of Carboxypeptidase A1/B1/A2 in mouse pancreas lysates using Carboxypeptidase A1/B1/A2 Recombinant Monoclonal Antibody (Product # MA567246).

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产品信息

MA567246

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293F

分类

Recombinant Monoclonal

类型

Antibody

克隆号

K01_4K18

抗原

A synthesized peptide derived from human Carboxypeptidase A1+A2+B.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

100 µg

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 0.05% BSA, 150mM NaCl, 50% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Carboxypeptidases A1, B1, and A2 (CPA1, CPB1, CPA2) are zinc-dependent exopeptidases produced as inactive zymogens in pancreatic acinar cells and activated in the intestinal lumen to complete protein digestion by trimming C-terminal amino acids from peptides. CPA1 and CPA2 preferentially remove hydrophobic or aromatic residues, while CPB1 removes basic residues like lysine and arginine, providing complementary substrate specificity to endopeptidases such as trypsin and chymotrypsin. These enzymes are encoded by distinct genes with high expression in the pancreas, secreted into the duodenum via the pancreatic duct, and stabilized by cofactors and pH conditions optimal for digestive function. Clinical relevance includes CPA1 variants linked to early-onset pancreatitis through misfolding stress, CPB1 as a biomarker in pancreatic injury, and altered carboxypeptidase activity in malabsorption and inflammatory states.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Carboxypeptidase A1; carboxypeptidase A1 (pancreatic); Carboxypeptidase A2; carboxypeptidase A2 (pancreatic); carboxypeptidase A2 (pancreatic) isoform CPA2_1; carboxypeptidase A2 (pancreatic) isoform CPA2_2; carboxypeptidase A2 (pancreatic) isoform CPA2_4; carboxypeptidase A2 (pancreatic) isoform CPA2_5; Carboxypeptidase B; Carboxypeptidase B1; carboxypeptidase B1 (tissue); CPA; CPA2A; CPB; Pancreas-specific protein; pancreatic carboxypeptidase A; Pancreatic carboxypeptidase A1; pancreatic carboxypeptidase B; pancreatic carboxypeptidase B1; PASP; PCPB; procarboxypeptidase B; protaminase; tissue carboxypeptidase B; unnamed protein product

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基因别名: 0910001A18Rik; 0910001L12Rik; 1810063F02Rik; 2210008M23Rik; AI504870; CPA; CPA1; CPA2; CPB; CPB1; PASP; PCPB