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Invitrogen
Carboxypeptidase A1/B1/A2 Recombinant Rabbit Monoclonal Antibody (K01_4K18)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA567246
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_4K18
抗原
A synthesized peptide derived from human Carboxypeptidase A1+A2+B.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA, 150mM NaCl, 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Carboxypeptidases A1, B1, and A2 (CPA1, CPB1, CPA2) are zinc-dependent exopeptidases produced as inactive zymogens in pancreatic acinar cells and activated in the intestinal lumen to complete protein digestion by trimming C-terminal amino acids from peptides. CPA1 and CPA2 preferentially remove hydrophobic or aromatic residues, while CPB1 removes basic residues like lysine and arginine, providing complementary substrate specificity to endopeptidases such as trypsin and chymotrypsin. These enzymes are encoded by distinct genes with high expression in the pancreas, secreted into the duodenum via the pancreatic duct, and stabilized by cofactors and pH conditions optimal for digestive function. Clinical relevance includes CPA1 variants linked to early-onset pancreatitis through misfolding stress, CPB1 as a biomarker in pancreatic injury, and altered carboxypeptidase activity in malabsorption and inflammatory states.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Carboxypeptidase A1; Carboxypeptidase A2; Carboxypeptidase B; Carboxypeptidase B1; CPA; CPA2A; CPB; Pancreas-specific protein; Pancreatic carboxypeptidase A1; pancreatic carboxypeptidase B1; PASP; PCPB
基因别名: 0910001A18Rik; 0910001L12Rik; 1810063F02Rik; 2210008M23Rik; AI504870; CPA; CPA1; CPA2; CPB; CPB1; PCPB
UniProt ID: (Mouse) Q7TPZ8, (Rat) P00731, (Mouse) Q504N0
Entrez Gene ID: (Mouse) 109697, (Rat) 24269, (Rat) 296959, (Mouse) 232680, (Mouse) 76703, (Rat) 24271
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
