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Proteintech
Carboxypeptidase B2 Polyclonal Antibody
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产品信息
10672-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carboxypeptidase B2 Fusion Protein Ag1110 (119-423 aa encoded by BC007057)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: YYEQYHSLN EIYSWIEFIT ERHPDMLTKI HIGSSFEKYP LYVLKVSGKE QAAKNAIWID CGIHAREWIS PAFCLWFIGH ITQFYGIIGQ YTNLLRLVDF YVMPVVNVDG YDYSWKKNRM WRKNRSFYAN NHCIGTDLNR NFASKHWCEE GASSSSCSET YCGLYPESEP EVKAVASFLR RNINQIKAYI SMHSYSQHIV FPYSYTRSKS KDHEELSLVA SEAVRAIEKT SKNTRYTHGH GSETLYLAPG GGDDWIYDLG IKYSFTIELR DTGTYGFLLP ERYIKPTCRE AFAAVSKIAW HVIRNV (119-423 aa encoded by BC007057)
靶标信息
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). CPB2 is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for its gene and its promoter region.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: carboxypeptidase B-like protein; Carboxypeptidase B2; carboxypeptidase B2 (plasma); carboxypeptidase B2 (plasma, carboxypeptidase U); Carboxypeptidase R; Carboxypeptidase U; CPR; CPU; pCPB; Plasma carboxypeptidase B; TAFI; Thrombin-activable fibrinolysis inhibitor; thrombin-activatable fibrinolysis inhibitor
基因别名: 1110032P04Rik; 4930405E17Rik; AI255929; CPB2; CPR; CPU; PCPB; TAFI
UniProt ID: (Human) Q96IY4, (Mouse) Q9JHH6, (Rat) Q9EQV9
Entrez Gene ID: (Human) 1361, (Mouse) 56373, (Rat) 113936
positive regulation of extracellular matrix constituent secretion
proteolysis
blood coagulation
response to heat
negative regulation of plasminogen activation
response to drug
fibrinolysis
negative regulation of fibrinolysis
cellular response to glucose stimulus
liver regeneration
negative regulation of hepatocyte proliferation
hemostasis
