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Caspase-2 Precursor (NT) Polyclonal Antibody
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产品信息
X1783P
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Rabbit polyclonal Caspase-2 antibody was raised against a 16 amino acid peptide from the amino-terminus of human Caspase-2.
偶联物
形式
Liquid
浓度
0.5-2 mg/mL
规格
100 µg
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive control: Expressed in larger amounts in the embryonic lung, liver and kidney than in the heart and brain. In the adults higher level expression is seen in the placenta, lung, kidney, pancreas than in the heart, brain, liver and skeletal muscle.
Depending on cell lines or tissues used, other cleavage products may be observed.
靶标信息
Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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