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Invitrogen
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MA1-24698 detects Caspase 4 from human and monkey samples.
MA1-24698 has been successfully used in Western blot procedures.
The MA1-24698 immunogen is a synthetic peptide, conjugated to KLH, corresponding to residues K(119) E R A E E I Y P I K E R N N(133) of human Caspase 4.
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。