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Proteintech
Caspase 9/p35/p10 Monoclonal Antibody (1B7G2)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
66169-1-IG
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
1B7G2
抗原
Caspase 9/p35/p10 Fusion Protein Ag20813 (141-392 aa encoded by BC002452)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.5 mg/mL
规格
225 µg
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: ALESLRGNA DLAYILSMEP CGHCLIINNV NFCRESGLRT RTGSNIDCEK LRRRFSSLHF MVEVKGDLTA KKMVLALLEL AQQDHGALDC CVVVILSHGC QASHLQFPGA VYGTDGCPVS VEKIVNIFNG TSCPSLGGKP KLFFIQACGG EQKDHGFEVA STSPEDESPG SNPEPDATPF QEGLRTFDQL DAISSLPTPS DIFVSYSTFP GFVSWRDPKS GSWYVETLDD IFEQWAHSED LQSLLLRVAN AVS (141-392 aa encoded by BC002452)
靶标信息
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: apoptotic protease activating factor 3; apoptotic protease MCH-6; apoptotic protease-activating factor 3; CASP9; caspase 9, apoptosis-related cysteine peptidase; caspase 9b; caspase-9 variant; ICE-like apoptotic protease 6; protein phosphatase 1, regulatory subunit 56; unnamed protein product
基因别名: APAF-3; APAF3; CASP-9; Caspase-9; ICE-LAP6; MCH6; PPP1R56
UniProt ID: (Human) P55211, (Mouse) Q8C3Q9
Entrez Gene ID: (Human) 842, (Mouse) 12371
response to hypoxia
kidney development
response to ischemia
proteolysis
apoptotic process
cellular response to DNA damage stimulus
intrinsic apoptotic signaling pathway in response to DNA damage
response to UV
protein processing
response to cobalt ion
response to estradiol
response to lipopolysaccharide
glial cell apoptotic process
cellular response to UV
signal transduction in response to DNA damage
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
response to ethanol
protein maturation
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to dexamethasone stimulus
response to indole-3-methanol
leukocyte apoptotic process
response to anesthetic
intrinsic apoptotic signaling pathway
positive regulation of execution phase of apoptosis
platelet formation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
