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Proteintech
Cathepsin A Polyclonal Antibody
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产品信息
15020-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Cathepsin A Fusion Protein Ag7073 (133-479 aa encoded by BC000597)
偶联物
形式
Liquid
浓度
0.46 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: FSYSDDKFY ATNDTEVAQS NFEALQDFFR LFPEYKNNKL FLTGESYAGI YIPTLAVLVM QDPSMNLQGL AVGNGLSSYE QNDNSLVYFA YYHGLLGNRL WSSLQTHCCS QNKCNFYDNK DLECVTNLQE VARIVGNSGL NIYNLYAPCA GGVPSHFRYE KDTVVVQDLG NIFTRLPLKR MWHQALLRSG DKVRMDPPCT NTTAASTYLN NPYVRKALNI PEQLPQWDMC NFLVNLQYRR LYRSMNSQYL KLLSSQKYQI LLYNGDVDMA CNFMGDEWFV DSLNQKMEVQ RRPWLVKYGD SGEQIAGFVK EFSHIAFLTI KGAGHMVPTD KPLAAFTMFS RFLNKQPY (133-479 aa encoded by BC000597)
靶标信息
The cathepsin family of proteolytic enzymes include several diverse classes of proteases. Cathepsins B, L, H, K, S and O comprise the cysteine protease class. Cathepsins D and E comprise the aspartyle protease class. The serine protease class includes cathepsin G. Cathepsins function in cellular metabolism and participate in peptide biosynthesis and protein degradation. Cathepsin A, a serine carboxypeptidase, exists in a high molecular weight lysosomal complex with b-galactosidase (b-gal) and a-neuraminidase (Neu1). Cathepsin A functions to protect b-gal and Neu1 from intralysosomal proteolysis. Deficiencies in cathepsin A lead to deficiencies in b-gal and Neu1. The gene encoding human cathepsin A maps to chromosome 20q13.12. Mutations in this gene cause glactosialidosis, a lysosomal storage disorder resulting from the b-gal and Neu1 deficiencies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: beta-galactosidase 2; beta-galactosidase protective protein; Carboxypeptidase C; Carboxypeptidase L; carboxypeptidase Y-like kininase; carboxypeptidase-L; Cathepsin A; deamidase; lysosomal carboxypeptidase A; Lysosomal protective protein; PPCA; Protective protein cathepsin A; Protective protein for beta-galactosidase; urinary kininase
基因别名: AU019505; CTSA; GLB2; GSL; NGBE; PPCA; PPGB
UniProt ID: (Human) P10619, (Mouse) P16675
Entrez Gene ID: (Human) 5476, (Mouse) 19025, (Rat) 296370
proteolysis
glycosphingolipid metabolic process
intracellular protein transport
regulation of protein stability
positive regulation of catalytic activity
proteolysis involved in cellular protein catabolic process
chaperone-mediated autophagy
regulation of chaperone-mediated autophagy
biological_process
