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GenScript

Cetuximab Recombinant Rabbit Monoclonal Antibody (90G3), MonoRab™

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产品信息

A01992-40

应用
建议稀释比
已发表文章

酶联免疫吸附实验 (ELISA)

0.01-0.1 µg/mL
-

抑制试剂 (Inhibition)

10-50 µg/mL
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

Mammalian cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

90G3

抗原

Cetuximab

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

规格

40 µg

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/mL.

Cetuximab is a recombinant human/mouse chimeric monoclonal antibody against epidermal growth factor receptor (EGFR). It is composed of the antigen-binding regions of mouse anti EGFR monoclonal antibody specific for the N-terminal portion of human EGFR with human IgG1 heavy and kappa light chain constant regions. Cetuximab is marketed under the brand Erbitux by Eli Lilly Company. It was approved by the US Food and Drug Administration for the treatment of metastatic colorectal cancer and metastatic non-small cell lung cancer.
GenScript MonoRab™ Anti-Cetuximab Antibody (90G3), mAb, Rabbit is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a rabbit immunized with Cetuximab.

Upon reconstitution, it can be stored for 2-3 weeks at 2-8 °C or for up to 12 months at -20 °C or below.

靶标信息

EGFR, epidermal growth factor receptor, is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. EGFR is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Cite this product

生物信息学

蛋白别名: 2.7.10.1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; contains extracellular domain; EC 2.7.10.1; epidermal growth factor receptor tyrosine kinase domain; erb-b2 receptor tyrosine kinase 1; GIG40; kinase EGFR; membrane protein; Oncogene ERBB; PIG61; proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; unnamed protein product; Urogastrone

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基因别名: ERBB; ERBB1; ERRP; HER1; mENA; NISBD2; NNCIS; PIG61

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UniProt ID: (Human) P00533

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Entrez Gene ID: (Human) 1956

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功能
chromatin binding double-stranded DNA binding protein kinase activity MAP kinase kinase kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane signaling receptor activity epidermal growth factor-activated receptor activity protein binding ATP binding kinase activity enzyme binding kinase binding protein phosphatase binding protein tyrosine kinase activator activity ubiquitin protein ligase binding identical protein binding cadherin binding epidermal growth factor binding actin filament binding ATPase binding
参与通路
MAPK cascade ossification positive regulation of protein phosphorylation signal transduction cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway learning or memory positive regulation of cell proliferation negative regulation of macroautophagy neuron differentiation positive regulation of cell growth positive regulation of cell migration positive regulation of peptidyl-serine phosphorylation positive regulation of toll-like receptor 9 signaling pathway ERBB2-EGFR signaling pathway negative regulation of epidermal growth factor receptor signaling pathway negative regulation of protein catabolic process positive regulation of phosphorylation negative regulation of apoptotic process positive regulation of MAPK cascade protein kinase B signaling positive regulation of DNA repair positive regulation of DNA replication positive regulation of transcription from RNA polymerase II promoter positive regulation of fibroblast proliferation positive regulation of epithelial cell proliferation regulation of peptidyl-tyrosine phosphorylation protein insertion into membrane positive regulation of protein kinase B signaling response to UV-A positive regulation of ERK1 and ERK2 cascade cellular response to amino acid stimulus cellular response to epidermal growth factor stimulus cellular response to estradiol stimulus positive regulation of protein kinase C signaling positive regulation of canonical Wnt signaling pathway cell-cell adhesion positive regulation of cGAS/STING signaling pathway positive regulation of G1/S transition of mitotic cell cycle positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of protein localization to plasma membrane negative regulation of cardiocyte differentiation
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