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Invitrogen
Chemerin Polyclonal Antibody
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Chemerin Antibody (PA5-47299) in Neu
Neutralization of Chemerin in BaF3 mouse pro‚B cell line transfected with human Chem R23. Samples were incubated in Chemerin polyclonal antibody (Product # PA5-47299). Recombinant Mouse Chemerin chemoattracts the BaF3 mouse pro‚B cell line transfected with human Chem R23 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin. Chemotaxis elicited by Recombinant Mouse Chemerin (100 ng/mL) is neutralized (green line) by increasing concentrations of Goat Ant... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-47299
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant mouse Chemerin Thr17-Ser156
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.2 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant human Chemerin is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
靶标信息
Retinoids act through ligand-dependent transcription factors, retinoid X receptor (RXRs) and retinoic acid receptors (RARs). Tazarotene-induced gene (TIG) proteins, also designated retinoic acid receptor responder proteins or RAR-responsive proteins, can be membrane bound or secreted. TIGs act as tumor suppressor genes in human cancers and are highly expressed in skin, hair follicles and endothelial cells as well as in pancreas, spleen and intestine. TIGs are activated by tazarotene and have been implicated as growth regulators that mediate the growth suppressive effects of retinoids. TIG2 is a secreted protein that is mainly expressed in epidermis, hair follicles and endothelial cells. TIG2 is inhibited in psoriatic lesions and is activated by tazarotene in skin rafts and in epidermis of psoriatic lesions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: chemerin; TIG-2; TIG2HP10433; unnamed protein product
基因别名: 0610007L05Rik
UniProt ID: (Mouse) Q9DD06
Entrez Gene ID: (Mouse) 71660
retinoid metabolic process
positive regulation of protein phosphorylation
positive regulation of systemic arterial blood pressure
inflammatory response
insulin receptor signaling pathway
positive regulation of macrophage chemotaxis
response to activity
antifungal humoral response
response to nutrient levels
developmental process
cellular response to insulin stimulus
innate immune response
positive regulation of fat cell differentiation
regulation of insulin receptor signaling pathway
embryonic digestive tract development
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
brown fat cell differentiation
positive regulation of chemotaxis
regulation of lipid catabolic process
antifungal innate immune response
response to caloric restriction
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