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Invitrogen
Climbazole Recombinant Mouse Monoclonal Antibody (5D8)
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Climbazole Antibody (MA566566) in SDS-PAGE
SDS-PAGE characterization of Climbazole under reducing conditions. Lane M: Protein marker (kDa); Lane CBZ: Purified Climbazole Recombinant Monoclonal (Product # MA566566). Climbazole showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-682.
产品信息
MA566566
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
5D8
抗原
Conjugate of CBZ hapten and KLH.
偶联物
形式
Liquid
浓度
5 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Climbazole is an antifungal imidazole compound widely used in pharmaceuticals and personal care products, notably in shampoos and lotions designed to treat dandruff and other fungal infections. Structurally, climbazole inhibits key enzymes involved in the synthesis of ergosterol, an essential component of the fungal cell membrane, thereby disrupting cell membrane integrity and preventing fungal growth. Beyond its therapeutic applications, research highlights environmental concerns associated with climbazole, as it is classified among persistent, mobile, and toxic (PMT) chemicals. Long-term environmental exposure, particularly in aquatic systems, raises potential ecological risks. Phototransformation products of climbazole in water cycles further emphasize the need for comprehensive assessment of its environmental impact. Additionally, issues such as solvent and temperature effects on climbazole's stability and efficacy are under investigation, indicating its complex behavior in diverse conditions. Despite its beneficial medical applications, climbazole's persistence in the environment necessitates careful monitoring and regulation to mitigate any potential ecological threats.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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