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Invitrogen
Clostridium botulinum Toxin B Recombinant Mouse Monoclonal Antibody (1C10)
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Clostridium botulinum Toxin B Antibody (MA566238) in SDS-PAGE
SDS-PAGE characterization of Clostridium botulinum Toxin B under reducing conditions. Lane M: Protein marker (kDa); Lane BTB-C: Purified Clostridium botulinum Toxin B Recombinant Monoclonal (Product # MA566238). Clostridium botulinum Toxin B showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-320.
产品信息
MA566238
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1C10
抗原
Botulinum toxin B.
偶联物
形式
Liquid
浓度
3.5 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Clostridium botulinum Toxin B (BoNT/B) is one of the protein neurotoxins produced by the bacteria Clostridium botulinum, which is a Gram-positive, anaerobic organism. BoNT/B, along with other botulinum toxins, is a primary virulence factor responsible for causing botulism, a serious and potentially fatal condition characterized by flaccid paralysis. BoNT/B specifically targets peripheral nerve terminals, inhibiting the release of neurotransmitters by cleaving synaptic vesicle-associated proteins, thus preventing synaptic vesicle fusion with the nerve terminal membrane. This blockade at neuromuscular junctions leads to prolonged muscle paralysis. Structurally, BoNT/B, like other botulinum toxins, consists of a heavy chain and a light chain connected by a disulfide bond. The heavy chain facilitates binding to neuronal cells and translocation into the cytosol, while the light chain acts as a protease to cleave specific proteins involved in neurotransmitter release.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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