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Invitrogen
Coprelotamab Humanized Recombinant Human Monoclonal Antibody
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产品信息
MA5-59195
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
Coprelotamab is a biosimilar monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2), also known as ERBB2. The ERBB2 gene, located on chromosome 17 at position 17q12, encodes the ErbB2 protein, also known as HER2 (human epidermal growth factor receptor 2). The ErbB2 protein is a member of the receptor tyrosine kinase family and is characterized by its extracellular domain, transmembrane segment, and intracellular tyrosine kinase domain. Structurally, the extracellular domain of ErbB2 forms a homodimer through a "back to head" interaction, which is critical for its function. ERBB2 is best known for its role in the pathogenesis of various cancers, particularly breast cancer. Overexpression or amplification of the ERBB2 gene leads to excessive ErbB2 protein on the cell surface, resulting in constant cell growth signaling. Unlike other members of the ErbB family, no specific ligand has been found for ErbB2, and its activation often involves heterodimerization with other ErbB family receptors such as EGFR. The activation of these receptors triggers downstream signaling pathways that promote cell proliferation and survival.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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