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Cyclin B1 Polyclonal Antibody

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
Cyclin B1 Polyclonal Antibody

产品信息

100-401-152

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-

免疫组化（石蜡） (IHC (P))

1:500
-

酶联免疫吸附实验 (ELISA)

1:2,000-1:10,000
-

免疫沉淀 (IP)

1:500-1:1,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Anti-Cyclin B1 antibody was produced by repeated immunizations of full length fusion protein corresponding to the human gene.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

80 mg/mL

保存液

whole serum

内含物

0.01% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Antiserum will specifically react with a 55-62 kDa Cyclin B1 protein from human, rat and mouse tissue. No reaction was observed against other related cyclins. Cross reactivity with Cyclin B1 from other species may also occur.

靶标信息

Cyclins bind to and regulate the activity of the Cyclin dependent protein kinases (CDKs). Cyclin B1 or CCNB1 is a regulatory protein involved in mitosis. It is essential for the control of the cell cycle at the G2/M transition. Cyclin B1 complexes with p34 (cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. Cyclin B1 is not ubiquitinated during G2/M phase, resulting in its steady accumulation during G2 phase, followed by abrupt APC dependent destruction at the end of mitosis. Destruction of Cyclin B1 is required for cell cycle progression. Cyclin B1 is overexpressed in various cancers, including breast, prostate, and non-small cell lung cancer.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: cyclin B1, related sequence 1; cyclin B1, related sequence 13; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1; OTTHUMP00000221981; OTTHUMP00000223023

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基因别名: Ccn-2; CCNB; CCNB1; Ccnb1-rs1; Ccnb1-rs13; Cycb; Cycb-4; Cycb-5; CycB1; Cycb1-rs1

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UniProt ID: (Human) P14635, (Rat) P30277, (Mouse) P24860

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Entrez Gene ID: (Human) 891, (Rat) 25203, (Mouse) 268697

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功能
cyclin-dependent protein serine/threonine kinase activity patched binding protein binding protein kinase binding histone kinase activity kinase activity protein complex binding kinase activator
参与通路
G2/M transition of mitotic cell cycle oocyte maturation in utero embryonic development negative regulation of protein phosphorylation protein complex assembly DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest mitotic spindle organization mitotic nuclear envelope disassembly mitotic metaphase plate congression spermatogenesis response to mechanical stimulus negative regulation of gene expression anaphase-promoting complex-dependent catabolic process positive regulation of mRNA 3'-end processing positive regulation of histone phosphorylation tissue regeneration response to drug protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of mitotic cell cycle response to DDT positive regulation of fibroblast proliferation digestive tract development cell division negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle regulation of cell cycle positive regulation of attachment of spindle microtubules to kinetochore ventricular cardiac muscle cell development positive regulation of cardiac muscle cell proliferation regulation of chromosome condensation cellular response to iron(III) ion cellular response to fatty acid cellular response to organic cyclic compound cellular response to hypoxia regulation of mitotic cell cycle spindle assembly checkpoint histone H3-S10 phosphorylation involved in chromosome condensation protein phosphorylation cell cycle mitotic nuclear division positive regulation of cell cycle
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