Progen

Cyclin D3 Monoclonal Antibody (DCS-22)

Name: Cyclin D3 Monoclonal Antibody (DCS-22)
Brand: Progen
SKU: 61064PROGEN

查看其他14个Cyclin D3抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (1)

Cyclin D3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Cyclin D3 Antibody (61064PROGEN) in IHC (P)

Immunohistochemistry analysis of human endocrine epithelial cells of the islets of Langerhans of the pancreas using anti-Cyclin D3 antibody (Cat. No. 61064). IHC was performed on formalin fixed paraffin embedded sections. The samples were deparaffinized with xylol and ethanol followed by heat induced antigen retrieval with 10 mM citrate buffer. After preparation the tissue was blocked with normal serum for ... View More

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Immunogen Image Cyclin D3 Monoclonal Antibody (DCS-22)

产品信息

61064PROGEN

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

免疫组化（石蜡） (IHC (P))

1:10

免疫组化（冰冻） (IHC (F))

1:10

产品规格

种属反应

Human, Mouse, Non-human primate

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

DCS-22

抗原

Human Recombinant Cyclin D3 Protein

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 0.5% BSA

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitute lyophilized product with 1 mL distilled water.

DCS-22 reacts specifically with cyclin D3. The antibody is useful for analysis of proliferation, detec-tion of cyclin D3 on tissue sections (suspected oncogene) and in cell cycle studies. The antibody does not cross-react with cyclin D1 and cyclin D2. Complementary reaction to the anti-cyclin D1/D2 antibodies.

靶标信息

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. Diseases associated with CCND3 include Retinoblastoma and Plasma Cell Leukemia.

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