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Invitrogen
Cyclophilin B Recombinant Rabbit Monoclonal Antibody (ST05-22)
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Cyclophilin B Antibody (MA5-32170) in IHC (P)
Immunohistochemistry analysis of Cyclophilin B with paraffin-embedded rat epididymis. The tissues were blocked in 5% BSA (30 min, room temp), washed with ddH2O and PBS, incubated with recombinant monoclonal Cyclophilin B (Product # MA5-32170) at a dilution of 1:200 (30 min, room temperature). Detection was performed with HRP, DAB was used as the chromogen, counterstained with hematoxylin and mounted with DP... View More
产品信息
MA5-32170
产品规格
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ST05-22
抗原
Synthetic peptide within Human Cyclophilin B aa 171-215
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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