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Invitrogen
Cytochrome C Antibody Cocktail
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Cytochrome C Antibody (459160) in WB
Western blot analysis of Cytochrome C in Jurkat, 143B, and HeLa cells using a Cytocrome C Monoclonal antibody (Product # 459160). Apoptosis was induced in Jurkat, 143B osteosarcoma, and HeLa cells bia treatment with FAS and staurosporine. Isolation of Mitochondrial and cytoplasmic fractions were performed before detecting with the Cyctocrome C Monoclonal antibody (Product # 459160). The western blot shows that Cytochrome c has translocated partially in FAS-induced cells and STS-treated 43B osteosarcoma cells, and almost completely in STS-t... View More
产品信息
459160
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ Ig
分类
Cocktail
类型
Antibody
克隆号
Cocktail
偶联物
形式
Liquid
浓度
0.9 mg/mL
纯化类型
IgG fraction
保存液
HEPES buffered saline
内含物
0.02% sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
ApoTrack™ Cytochrome c WB Cocktail (Sku# 459160) provides a means to detect apoptosis while detecting release of cytochrome c, as well as a cytoplasmic and mitochondrial markers with the help of western blot. This cocktail provides a means to detect cytochrome c, as well as a cytoplasmic and mitochondrial markers
Antibodies Cocktail Contains:
Mouse anti Cyt. c monoclonal:
Amount: 50 µg
Working concentration: 1 µg/mL
Mouse anti GAPDH monclonal:
Amount: 5 µg
Working concentration: 0.1 µg/mL
Mouse anti PDH-E1-alpha monoclonal:
Amount: 100 µg
Working concentration: 2 µg/mL
Mouse anti C-V-alpha monoclonal:
Amount: 25 µg
Working concentration: 0.5 µg/mL
靶标信息
Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in oxidative phosphorylation and the production of cellular ATP. Release of cytochrome C from the mitochondria to the cytosol is triggered by apoptotic stimuli. In the cytoplasm, the cytochrome C binds apoptotic protease activating factor which activates the apoptotic initiator procaspase 9. Cytosolic cytochrome C functions in the activation of caspase 3, an ICE family molecule that is a key effector of apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CRF; CYCS; Cytochrome c; hc1; unnamed protein product
基因别名: CYC; CYCS; HCS; THC4
UniProt ID: (Human) P99999
Entrez Gene ID: (Human) 54205
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