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Invitrogen
Cytokeratin 14/17 Monoclonal Antibody (EBS-IF-005)
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产品信息
MA5-33318
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Mouse
/ IgM, kappa
分类
Monoclonal
类型
Antibody
克隆号
EBS-IF-005
抗原
Cytokeratin-enriched extract of human ectocervical epithelium
偶联物
形式
Liquid
浓度
125 µg/mL
保存条件
4°C, do not freeze
运输条件
Wet ice (domestic); Dry ice (international)
RRID
产品详细信息
MA5-33318 reacts in immunoblotting specifically with keratin 14 (50kDa). In tissue sections MA5-33318 is positive on basal cells of non-keratinizing stratified epithelia, basal cells and suprabasal cells of the epidermis and gingiva, myoepithelial cells and squamous cell carcinomas.
靶标信息
Cytokeratins(CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie. Skin) and non-keratinizing cells (ie. Mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different CKs in the molecular range of 40-70 k Da and isoelectric points of 5-805 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. Belonging to the type A (acidic) subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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