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MUbio
Cytokeratin 14/Keratin K14 Monoclonal Antibody (RCK107)
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产品信息
MUB0323P
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Human,
Pig,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
RCK107
抗原
Cytokeratin 14 / Keratin K14
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
RCK107 reacts exclusively with Cytokeratin 14 which is present in basal cell compartments of stratified and combined epithelia.
The antibody may be stored at 4°C. For prolonged storage prepare appropriate aliquots and store at or below -20°C. Prior to use, an aliquot is thawed slowly in the dark at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at 4°C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance or the concentration of the product.
靶标信息
Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie. skin) and non-keratinizing cells (ie. mesothelial cells). At least 20 different CKs can be identified. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). Belonging to the type I subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas. At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CK-14; cytokeratin 14; cytokeratin-14; K14; keratin 14; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin complex 1, acidic, gene 14; Koebner; type I keratin Ka14
基因别名: CK14; EBS1; EBS1A; EBS1B; EBS1C; EBS1D; EBS3; EBS4; K14; Ka14; Krt1-14; KRT14; NFJ
UniProt ID: (Human) P02533, (Rat) Q6IFV1
Entrez Gene ID: (Human) 3861, (Dog) 100685323, (Rat) 287701, (Pig) 100737113
morphogenesis of an epithelium
epidermis development
keratinocyte differentiation
hair cycle
intermediate filament organization
intermediate filament bundle assembly
positive regulation of keratinocyte differentiation
response to radiation
response to zinc ion
response to ionizing radiation
epithelial cell differentiation
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