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Invitrogen
Cytokeratin 8 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-29607
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat,
Zebrafish
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human Cytokeratin 8. The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.12 mg/mL
规格
12 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol, 1% BSA
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: HepG2, HeLa, mouse liver, rat liver.
Predicted reactivity: Mouse (96%), Rat (95%), Zebrafish (83%), Xenopus laevis (85%), Dog (91%), Pig (91%), Rhesus Monkey (99%), Bovine (90%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Cytokeratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. Cutokeratin 8 typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CK-8; cytokeratin 8; cytokeratin endo A; cytokeratin-8; EndoA cytokeratin (5' end put.); putative; EndoA' cytokeratin (5' end put.); putative; etID33550.23; etID43142.23; etID43142.8; intermediate filament; K8; keratin 8, type II; keratin complex 2, basic, gene 8; keratin, type 2, gene 8; type-II keratin Kb8; unnamed protein product
基因别名: CARD2; cb186; CK-8; CK8; CYK8; CYKER; DreK8; EndoA; K2C8; K8; KO; Krt-2.8; Krt2-8; sb:cb186; TROMA-1; wu:fa20h05; wu:fa95h10; wu:fb96c06; zf-K8; zfk8
UniProt ID: (Human) P05787, (Mouse) P11679, (Rat) Q10758, (Zebrafish) Q6NWF6
Entrez Gene ID: (Human) 3856, (Mouse) 16691, (Rat) 25626, (Zebrafish) 797433
intermediate filament organization
sarcomere organization
epithelium development
negative regulation of hepatocyte apoptotic process
tumor necrosis factor-mediated signaling pathway
response to hydrostatic pressure
response to other organism
cell differentiation involved in embryonic placenta development
extrinsic apoptotic signaling pathway
hepatocyte apoptotic process
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