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Progen
Cytokeratin 8 Monoclonal Antibody (Ks8-17.2)
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产品信息
65130
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Hamster,
Human,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
Ks8-17.2
抗原
Cytoskeletal Proteins From Human Tumor Cell Line Mcf-7
偶联物
形式
Liquid
浓度
Conc. Not Determined
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Ks 8-17.2 represents an excellent marker to discriminate simple epithelia from those of different origin.Tumors specifically detected: All adeno-CA tested; undifferentiated CA; cervix CA; hepatocellular CA. Polypeptide reacting: MW 52 500 polypeptide (keratin K8; formerly also designated cytokeratin 8) of human epithelia.Reactivity on cultured cell lines: MCF-7, HeLa, A-431, PLC, Detroit 562.
靶标信息
Cytokeratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. Cutokeratin 8 typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CK-8; cytokeratin 8; Cytokeratin endo A; Cytokeratin-8; Cytokeratin-A; K8; KERA; keratin 8; keratin 8, type II; keratin complex 2, basic, gene 8; Keratin, type II cytoskeletal 8; keratin, type II cytoskeletal 8-like protein; Keratin-8; type II cytokeratin A (no.8); Type-II keratin Kb8
基因别名: CARD2; CK-8; CK8; CYK8; CYKER; K2C8; K8; KO; KRT2-8; KRT8
UniProt ID: (Bovine) P05786, (Human) P05787, (Rat) Q10758
Entrez Gene ID: (Bovine) 281269, (Human) 3856, (Chinese hamster) 100759488, (Rat) 25626
