AbboMax

Cytokeratin (HMW) Monoclonal Antibody (34bE12)

Name: Cytokeratin (HMW) Monoclonal Antibody (34bE12)
Brand: AbboMax
SKU: 605-340

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (1)

Cytokeratin (HMW) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Cytokeratin (HMW) Antibody (605-340) in IHC (P)

Immunohistochemistry: Human prostate carcinoma (FFPE) stained with Mouse anti- Cytokeratin (HMW) (Cat# 605-340) at 1:200 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

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产品信息

605-340

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

2-10 µg/mL

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

34bE12

抗原

A synthetic peptide of Cytokeratin (HMW)

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS with proprietary stabilizer

内含物

0.01% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Positive control: Skin

Cellular location: Cytoplasmic.

靶标信息

Keratins are heteropolymeric structural proteins that form the intermediate filament. Cytokeratins are intermediate filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue. There are two types of cytokeratins - the low weight, acidic type I and the high weight, basic type II. Cytokeratins are usually found in pairs - one type I and one type II. KRT1 regulates the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase I (RACK1). In complex with C1QBP it is a high affinity receptor for kininogen-1/HMWK. KRT1 is expressed in the spinous and granular layers of the epidermis with family member KRT10. Mutations affecting the gene result in bullous congenital ichthyosiform erythroderma. KRT5 is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations affecting the gene result in epidermolysis bullosa simplex diseases. KRT10 plays a role in the establishment of the epidermal barrier on plantar skin. It also acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB - thus it plays a role in nasal colonization. Mutations affecting the gene result in epidermolytic hyperkeratosis. KRT14's nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. Mutations affecting the gene result in epidermolysis bullosa simplex.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: 58 kDa cytokeratin; 67 kDa cytokeratin; CK-1; CK-10; CK-14; CK-5; cytokeratin 1; cytokeratin 10; cytokeratin 14; Cytokeratin-1; Cytokeratin-10; Cytokeratin-14; Cytokeratin-5; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; epidermolytic hyperkeratosis 1; Hair alpha protein; K1; K10; K14; K5; keratin 1, type II; keratin 10, type I; keratin 14, type I; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 14; Keratin, type II cytoskeletal 1; Keratin, type II cytoskeletal 5; Keratin-1; Keratin-10; Keratin-14; Keratin-5; Type-II keratin Kb1; Type-II keratin Kb5

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基因别名: BCIE; BIE; CK1; CK10; CK14; CK5; DDD; DDD1; EBS2; EBS3; EBS4; EHK; EHK1; EPPK; K1; K10; K14; K5; KPP; KRT1; KRT10; KRT14; KRT1A; KRT5; KRT5A; KRTA; NEPPK; NFJ