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Invitrogen
Cytokeratin Pan Type I Monoclonal Antibody (AE1)
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产品信息
MA1-5761
应用
建议稀释比
已发表文章
产品规格
种属反应
Rat,
Bovine,
Chicken,
Human,
Mouse,
Non-human primate,
Pig,
Rabbit
已发表种属
Human,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
AE1
抗原
Human epidermal keratins from P3 x 63 Ag8 cells
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA1-5761 detects most human acidic (type I) keratins K10, K14, K15, K16, K19.
MA1-5761 has been successfully used in Western blot, immunomicroscopy and immunohistochemistry (paraffin) procedures. For Western blotting, do not use milk for blocking nonspecific binding because it contains some keratins (bovine serum albumin is recommended).
The MA1-5761 immunogen is human epidermal keratins.
靶标信息
Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 40-kDa keratin intermediate filament; 56 kDa cytokeratin; Acidic Cytokeratin; alpha keratin; Cell proliferation-inducing gene 46 protein; CK-10; CK-14; CK-15; CK-16; CK-18; CK-19; CK-9; cytokeratin 10; cytokeratin 14; cytokeratin 15; cytokeratin 16; cytokeratin 18; cytokeratin 19; cytokeratin 9; Cytokeratin endo B; Cytokeratin VIB; cytokeratin VII; Cytokeratin-10; Cytokeratin-14; Cytokeratin-15; Cytokeratin-16; Cytokeratin-18; Cytokeratin-19; Cytokeratin-6B; cytokeratin-7; Cytokeratin-9; Endo B; epidermal keratin 10; epidermal keratin VII; epidermolysis bullosa simplex, Dowling-Meara, Koebner; epidermolytic hyperkeratosis; keratosis palmaris et plantaris; focal non-epidermolytic palmoplantar keratoderma; GK-19; HMWCK; intermediate filament protein; K10; K14; K15; K16; K18; K19; K9; keratin 10 (epidermolytic hyperkeratosis); keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris); keratin 10, type I; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin 15; keratin 15, type I; keratin 16, type I; keratin 18, type I; keratin 19; keratin 19, type I; keratin 9 (epidermolytic palmoplantar keratoderma); keratin 9, type I; keratin complex 1, acidic, gene 10; keratin complex 1, acidic, gene 14; keratin complex 1, acidic, gene 15; keratin complex 1, acidic, gene 16; keratin complex 1, acidic, gene 18; keratin complex 1, acidic, gene 19; keratin complex 1, acidic, gene 9; Keratin D; keratin intermediate filament 16a; keratin intermediate filament 16b; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 15; Keratin, type I cytoskeletal 16; Keratin, type I cytoskeletal 18; Keratin, type I cytoskeletal 19; Keratin, type I cytoskeletal 59 kDa; Keratin, type I cytoskeletal 9; keratin, type I, 40-kd; Keratin-10; Keratin-14; Keratin-15; keratin-15, basic; keratin-15, beta; Keratin-16; Keratin-18; Keratin-19; Keratin-9; krt10 {ECO:0000250|UniProtKB:P13645}; krt15 {ECO:0000250|UniProtKB:P19012}; krt18 {ECO:0000250|UniProtKB:P05783}; krt9; pan keratin; pankeratin; Spermatid perinuclear ring manchette protein K9; suprabasal cytokeratin 10; type I alpha-keratin 14; type I alpha-keratin 15; type I cytoskeletal 15; type I cytoskeletal 9; type I keratin KA10; Type I keratin Ka14; Type I keratin Ka15; type I keratin KA16; Type I keratin Ka19; unnamed protein product
基因别名: AI324768; AI528832; AI626930; AI663979; BCIE; BIE; CK-14; CK-18; CK-9; CK10; CK14; CK15; CK16; CK18; CK19; CYK18; D130054E02Rik; EBS3; EBS4; EHK; EndoC; EPPK; FNEPPK; GK-19; K10; K14; K15; K16; K18; K19; K1C1; K1CO; K1CP; K1CS; K9; Ka10; Ka14; Ka15; Ka16; Ka19; keratin-19; Kerd; KPP; Krt-1.10; Krt-1.14; Krt-1.19; Krt1-10; Krt1-14; Krt1-15; Krt1-16; Krt1-18; Krt1-19; Krt1-9; KRT10; KRT14; KRT15; KRT16; KRT16A; KRT18; KRT19; KRT9; KRTB; NEPPK; NFJ; PC1; PIG46
UniProt ID: (Bovine) P06394, (Human) P13645, (Human) P02533, (Chicken) Q6PVZ1, (Human) P19012, (Human) P08779, (Human) P05783, (Bovine) P08728, (Human) P08727, (Chicken) O93256, (Human) P35527, (Mouse) P02535, (Rat) Q6IFV1, (Mouse) Q61781, (Mouse) Q61414, (Rat) Q6IFV3, (Mouse) Q9Z2K1, (Rat) Q5BJY9, (Mouse) P05784, (Rat) Q63279, (Mouse) P19001, (Mouse) Q6RHW0, (Rat) Q8CIS9
Entrez Gene ID: (Bovine) 281888, (Chicken) 771977, (Rabbit) 100009029, (Human) 3858, (Pig) 100519971, (Chicken) 408040, (Human) 3861, (Bovine) 404111, (Chicken) 408039, (Rabbit) 100341120, (Pig) 100515506, (Bovine) 507464, (Human) 3866, (Rabbit) 100341376, (Human) 3868, (Rabbit) 100354174, (Chicken) 101749333, (Human) 3875, (Bovine) 506480, (Pig) 100126286, (Bovine) 514812, (Human) 3880, (Pig) 100515339, (Chicken) 395861, (Human) 3857, (Mouse) 16661, (Rat) 450225, (Rat) 287701, (Mouse) 16664, (Mouse) 16665, (Rat) 287700, (Rat) 303530, (Mouse) 16666, (Rat) 294853, (Mouse) 16668, (Rat) 360626, (Mouse) 16669, (Mouse) 107656, (Rat) 266717
structural molecule activity
protein heterodimerization activity
structural constituent of epidermis
structural constituent of cytoskeleton
protein binding
keratin filament binding
scaffold protein binding
poly(A) RNA binding
cadherin binding involved in cell-cell adhesion
structural constituent of muscle
protein complex binding
molecular_function
mitophagy in response to mitochondrial depolarization
Notch signaling pathway
response to estrogen
sarcomere organization
cell differentiation involved in embryonic placenta development
epithelial cell differentiation
cellular response to calcium ion
morphogenesis of an epithelium
inflammatory response
aging
biological_process
keratinocyte differentiation
negative regulation of cell migration
keratinization
hair cycle
innate immune response
intermediate filament cytoskeleton organization
keratinocyte migration
establishment of skin barrier
cell cycle
anatomical structure morphogenesis
viral process
tumor necrosis factor-mediated signaling pathway
Golgi to plasma membrane CFTR protein transport
negative regulation of apoptotic process
extrinsic apoptotic signaling pathway
hepatocyte apoptotic process
cell-cell adhesion
response to zinc ion
response to ionizing radiation
intermediate filament bundle assembly
positive regulation of epidermis development
protein heterotetramerization
spermatogenesis
epidermis development
hemidesmosome assembly
skin development
intermediate filament organization
immune system process
cytoskeleton organization
cell proliferation
intermediate filament-based process
