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Invitrogen
DACH1 Polyclonal Antibody
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DACH1 Antibody (PA5-93268) in WB
Western blot analysis of DACH1 in 293F cells. Samples were incubated with DACH1 Polyclonal antibody (Product # PA5-93268) using a dilution of 1:900, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
产品信息
PA5-93268
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 450-570 of human DACH1 (NP_5429372)
偶联物
形式
Liquid
浓度
2.96 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: EGRRPGSHPS SHRSSSVSSS PARTESSSDR IPVHQNGLSM NQMLMGLSPN VLPGPKEGDL AGHDMGHESK RMHIEKDETP LSTPTARDSL DKLSLTGHGQ PLPPGFPSPF LFPDGLSSIE T; Positive Samples: Mouse kidney, Mouse lung, Mouse heart, Rat kidney, Rat heart, Rat heart; Cellular Location: Nucleus
靶标信息
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dach1; dachshund family transcription factor 1; Dachshund homolog 1; FLJ10138; OTTHUMP00000040839; RP11-512J14.1
基因别名: Dac; Dach; Dach1
UniProt ID: (Mouse) Q9QYB2
Entrez Gene ID: (Rat) 306096, (Mouse) 13134
transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
DNA binding
protein binding
winged helix/forkhead transcription factor
negative regulation of transcription from RNA polymerase II promoter
suckling behavior
regulation of transcription, DNA-templated
respiratory gaseous exchange
cell proliferation
negative regulation of transcription by competitive promoter binding
negative regulation of cell migration
development of primary female sexual characteristics
negative regulation of fibroblast proliferation
RNA polymerase II transcriptional preinitiation complex assembly
negative regulation of cell proliferation involved in contact inhibition
transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
negative regulation of transcription, DNA-templated
negative regulation of DNA biosynthetic process
