Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Bioss
DAPK1/2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
BS-1713R
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human DAPK2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation. Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: DAP kinase 1; DAP kinase 2; DAP-kinase-related protein 1; DAP-kinase-related protein 1 beta isoform; death-associated kinase 2; Death-associated protein kinase 1; Death-associated protein kinase 2; DRP-1
基因别名: D13Ucla1; DAP-Kinase; DAPK; DAPK1; DAPK2; DRP-1; DRP1
UniProt ID: (Human) P53355, (Human) Q9UIK4, (Mouse) Q80YE7, (Mouse) Q8VDF3
Entrez Gene ID: (Human) 1612, (Human) 23604, (Rat) 306722, (Mouse) 69635, (Rat) 300799, (Mouse) 13143
protein kinase activity
protein serine/threonine kinase activity
calmodulin-dependent protein kinase activity
protein binding
calmodulin binding
ATP binding
GTP binding
syntaxin-1 binding
identical protein binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
immunoglobulin
protein phosphorylation
apoptotic process
extrinsic apoptotic signaling pathway via death domain receptors
regulation of autophagy
negative regulation of translation
intracellular signal transduction
regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein autophosphorylation
cellular response to interferon-gamma
apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of N-methyl-D-aspartate selective glutamate receptor activity
anoikis
positive regulation of neutrophil chemotaxis
neutrophil migration
positive regulation of eosinophil chemotaxis
regulation of intrinsic apoptotic signaling pathway
negative regulation of apoptotic process
regulation of translation
signal transduction
phosphorylation
