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Invitrogen
DDRGK1 Polyclonal Antibody
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产品信息
PA5-100467
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human DDRGK1(Accession Q96HY6), corresponding to amino acid residues P35-W85.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total DDRGK1.
靶标信息
Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription. May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B. May also play a role in the cellular response to endoplasmic reticulum stress.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dashurin; DDRGK domain-containing protein 1; UFM1-binding and PCI domain-containing protein 1; UFM1-binding protein 1 containing a PCI domain
基因别名: 1110001I20Rik; 2600009E05Rik; AI326138; C20orf116; DDRGK1; dJ1187M17.3; UFBP1
UniProt ID: (Human) Q96HY6, (Mouse) Q80WW9
Entrez Gene ID: (Human) 65992, (Mouse) 77006
regulation of intracellular estrogen receptor signaling pathway
response to endoplasmic reticulum stress
positive regulation of NF-kappaB transcription factor activity
positive regulation of proteasomal protein catabolic process
positive regulation of I-kappaB phosphorylation
protein K69-linked ufmylation
