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Bioss
DENND1A Polyclonal Antibody
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DENND1A Antibody (BS-14269R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Rat brain; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with DENND1A Polyclonal Antibody, Unconjugated (bs-14269R) at 1:500 overnight at 4°C, DAB staining.
产品信息
BS-14269R
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human DENND1A, amino acids 42-140.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Clathrin-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2). Thus, connecdenns link RAB35 activation with the clathrin machinery.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Connecdenn; Connecdenn 1; DENN domain-containing protein 1A; DENN/MADD domain containing 1A; Protein FAM31A; RP11-230L22.3
基因别名: 6030446I19Rik; connecdenn; DENND1A; FAM31A; KIAA1608; RGD1307927
UniProt ID: (Human) Q8TEH3, (Mouse) Q8K382
Entrez Gene ID: (Human) 57706, (Rat) 311913, (Mouse) 227801
