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DJ-1 Monoclonal Antibody (GT1412)

查看其他30个DJ-1抗体

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DJ-1 Monoclonal Antibody (GT1412)

产品信息

MA5-42335

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:10,000
-
产品规格

种属反应

Human

宿主/亚型

Mouse / IgG3

分类

Monoclonal

类型

Antibody

克隆号

GT1412

抗原

Full length human Park7 / DJ-1 recombinant protein.
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.33 mg/mL

规格

133 µg

纯化类型

Protein A

保存液

PBS

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2911476

产品详细信息

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

靶标信息

The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CTA-215D11.1; early onset 7; epididymis secretory sperm binding protein Li 67p; FLJ27376; FLJ34360; FLJ92274; maillard deglycase; oncogene DJ1; OTTHUMP00000001350; OTTHUMP00000001351; PARK7 GENE; PARK7/DJ1; Parkinson disease (autosomal recessive, early onset) 7; parkinson protein 7; protein deglycase DJ-1; protein DJ-1; protein/nucleic acid deglycase DJ-1; unnamed protein product

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基因别名: DJ-1; DJ1; GATD2; HEL-S-67p

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UniProt ID: (Human) Q99497

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Entrez Gene ID: (Human) 11315

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功能
core promoter sequence-specific DNA binding double-stranded DNA binding single-stranded DNA binding transcription coactivator activity mRNA binding receptor binding copper ion binding protein binding enzyme activator activity peptidase activity superoxide dismutase copper chaperone activity oxidoreductase activity, acting on peroxide as acceptor oxygen sensor activity enzyme binding kinase binding cytokine binding peptidase inhibitor activity receptor activator activity tyrosine 3-monooxygenase activator activity L-dopa decarboxylase activator activity protein deglycase activity identical protein binding protein homodimerization activity small protein activating enzyme binding ubiquitin-like protein conjugating enzyme binding cadherin binding mercury ion binding androgen receptor binding peroxiredoxin activity ubiquitin-protein transferase inhibitor activity scaffold protein binding DNA-binding transcription factor binding cupric ion binding cuprous ion binding ubiquitin-specific protease binding glyoxalase (glycolic acid-forming) activity
参与通路
positive regulation of acute inflammatory response to antigenic stimulus DNA repair response to oxidative stress mitochondrion organization Ras protein signal transduction methylglyoxal metabolic process detoxification of copper ion positive regulation of gene expression negative regulation of gene expression lactate biosynthetic process removal of superoxide radicals insulin secretion protein repair androgen receptor signaling pathway positive regulation of protein complex assembly negative regulation of protein ubiquitination negative regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of TRAIL production positive regulation of interleukin-8 production negative regulation of protein sumoylation response to testosterone cellular response to oxidative stress cellular response to glyoxal negative regulation of protein catabolic process glucose homeostasis hydrogen peroxide metabolic process regulation of neuron apoptotic process negative regulation of neuron apoptotic process positive regulation of transcription from RNA polymerase II promoter glycolate biosynthetic process negative regulation of protein export from nucleus regulation of inflammatory response detoxification of mercury ion protein stabilization regulation of mitochondrial membrane potential positive regulation of protein kinase B signaling regulation of androgen receptor signaling pathway detoxification of hydrogen peroxide cellular response to hydrogen peroxide detection of oxidative stress cellular detoxification of aldehyde cellular detoxification of methylglyoxal positive regulation of protein localization to nucleus regulation of synaptic vesicle endocytosis negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway regulation of fibril organization positive regulation of mitochondrial electron transport, NADH to ubiquinone negative regulation of death-inducing signaling complex assembly negative regulation of protein K48-linked deubiquitination negative regulation of TRAIL-activated apoptotic signaling pathway positive regulation of dopamine biosynthetic process glyoxal metabolic process glyoxal catabolic process regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway negative regulation of reactive oxygen species biosynthetic process positive regulation of mitophagy negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway positive regulation of reactive oxygen species metabolic process negative regulation of extrinsic apoptotic signaling pathway
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