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Invitrogen
DLL4 Polyclonal Antibody
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产品信息
PA5-29016
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide encompassing a sequence within the Extracellular domain of human DLL4. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: Raji, HUVEC.
Predicted reactivity: Pig (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: delta 4; delta ligand 4; delta-like 4 homolog; delta-like 4 protein; Delta-like protein 4; Delta4; Drosophila Delta homolog 4; MGC126344; notch ligand delta-2; notch ligand DLL4
基因别名: AOS6; DLL4; hdelta2; UNQ1895/PRO4341
UniProt ID: (Human) Q9NR61
Entrez Gene ID: (Human) 54567
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
patterning of blood vessels
blood vessel remodeling
cardiac ventricle morphogenesis
cardiac atrium morphogenesis
ventricular trabecula myocardium morphogenesis
pericardium morphogenesis
signal transduction
Notch signaling pathway
Notch receptor processing
visual perception
blood circulation
negative regulation of cell proliferation
negative regulation of endothelial cell migration
positive regulation of gene expression
negative regulation of gene expression
T cell differentiation
dorsal aorta morphogenesis
cellular response to vascular endothelial growth factor stimulus
cellular response to fibroblast growth factor stimulus
negative regulation of Notch signaling pathway
positive regulation of Notch signaling pathway
regulation of neurogenesis
ventral spinal cord interneuron fate commitment
regulation of neural retina development
Notch signaling involved in heart development
blood vessel lumenization
negative regulation of cell migration involved in sprouting angiogenesis
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
positive regulation of neural precursor cell proliferation
