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Proteintech
DNA polymerase beta Polyclonal Antibody
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产品信息
18003-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
DNA polymerase beta Fusion Protein Ag12496 (1-335 aa encoded by BC100288)
偶联物
形式
Liquid
浓度
0.33 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MSKRKAPQE TLNGGITDML TELANFEKNV SQAIHKYNAY RKAASVIAKY PHKIKSGAEA KKLPGVGTKI AEKIDEFLAT GKLRKLEKIR QDDTSSSINF LTRVSGIGPS AARKFVDEGI KTLEDLRKNE DKLNHHQRIG LKYFGDFEKR IPREEMLQMQ DIVLNEVKKV DSEYIATVCG SFRRGAESSG DMDVLLTHPS FTSESTKQPK LLHQVVEQLQ KVHFITDTLS KGETKFMGVC QLPSKNDEKE YPHRRIDIRL IPKDQYYCGV LYFTGSDIFN KNMRAHALEK GFTINEYTIR PLGVTGVAGE PLPVDSEKDI FDYIQWKYRE PKDRSE (1-335 aa encoded by B C100288)
靶标信息
DNA polymerase beta comprises an amino-terminal 8- kDa domain and a carboxy-terminal 31- kDa domain. The N-terminal ssDNA binding domain has a deoxyribose phosphodiesterase activity while the C-terminal domain has a nucleotidyltransferase activity. Mammalian DNA polymerase beta, a DNA repair polymerase, is constitutively expressed in cultured cells, but treatment of cells with the DNA-alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or methyl methanesulfonate up-regulates beta-pol level. DNA polymerase beta fills single nucleotide gaps in DNA produced by the base excision repair pathway of mammalian cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 5'-deoxyribose-phosphate lyase; 5'-dRP lyase; AP lyase; DNA pol beta; DNA polymerase beta; DNA polymerase beta subunit; DNA-directed DNA polymerase beta; MGC125976; POL B; Pol beta; polymerase (DNA directed), beta; polymerase (DNA) beta; polymerase B; polymerase-beta
基因别名: A430088C08Rik; POLB
UniProt ID: (Human) P06746, (Rat) P06766, (Mouse) Q8K409
Entrez Gene ID: (Human) 5423, (Rat) 29240, (Mouse) 18970
damaged DNA binding
DNA-directed DNA polymerase activity
DNA-(apurinic or apyrimidinic site) lyase activity
protein binding
microtubule binding
lyase activity
enzyme binding
metal ion binding
DNA binding
transferase activity
nucleotidyltransferase activity
DNA polymerase activity
DNA-directed DNA polymerase
DNA-dependent DNA replication
DNA repair
base-excision repair
base-excision repair, base-free sugar-phosphate removal
base-excision repair, gap-filling
base-excision repair, DNA ligation
pyrimidine dimer repair
nucleotide-excision repair, DNA gap filling
inflammatory response
cellular response to DNA damage stimulus
salivary gland morphogenesis
aging
intrinsic apoptotic signaling pathway in response to DNA damage
response to gamma radiation
somatic hypermutation of immunoglobulin genes
response to ethanol
lymph node development
spleen development
homeostasis of number of cells
neuron apoptotic process
response to hyperoxia
immunoglobulin heavy chain V-D-J recombination
DNA biosynthetic process
DNA replication
apoptotic process
somatic diversification of immunoglobulins
