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Invitrogen
DNMT3B Polyclonal Antibody
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产品信息
PA1-20850
产品规格
宿主/亚型
Chicken
/ IgY
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment, corresponding to amino acids 271-446 of Human Dnmt3b.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
PA1-20850 detects DNA Methyl Transferase 3b in human and mouse samples.
PA1-20850 has been successfully used in immunocytochemistry and Western blot procedures.
The PA1-20850 immunogen is a recombinant fragment, corresponding to amino acids 271-446 of human DNA Methyl Transferase 3b.
靶标信息
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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