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Invitrogen
DNMT3B Polyclonal Antibody
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产品信息
PA1-27947
产品规格
宿主/亚型
Chicken
/ IgY
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to human DNA cytosine-5 methyltransferase 3 beta isoform 6 variant.
偶联物
形式
Liquid
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
PA1-27947 detects ICF from human and mouse samples.
PA1-27947 may be successfully used in Western blot applications. By Western blot, this antibody has only been tested on fusion protein.
The PA1-27854 immunogen is a synthetic peptide corresponding to human DNA cytosine-5 methyltransferase 3 beta isoform 6 variant.
靶标信息
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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