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Invitrogen
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Immunogen sequence: RELKEKVEKH YGVITLPPNL TERKQSRTGS IVLPYIMSST LRRLSITSVT SSVVSTSSNS SDNAPSRPGS DGSILEPLLE RRASSGARVE DLSLREENSE NRISKFKRKD WSLSKSQVIA EKAPEPDLMS PTRKAQR
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 85%.
Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).
仅用于科研。不用于诊断过程。未经明确授权不得转售。