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Proteintech
DOK7 Polyclonal Antibody
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产品信息
22697-1-AP
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
DOK7 Fusion Protein Ag18543 (136-504 aa encoded by BC131544)
偶联物
形式
Liquid
浓度
0.43 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: DVLVLARDI PPAVTGQWKL SDLRRYGAVP SGFIFEGGTR CGYWAGVFFL SSAEGEQISF LFDCIVRGIS PTKGPFGLRP VLPDPSPPGP STVEERVAQE ALETLQLEKR LSLLSHAGRP GSGGDDRSLS SSSSEASHLD VSASSRLTAW PEQSSSSAST SQEGPRPAAA QAAGEAMVGA SRPPPKPLRP RQLQEVGRQS SSDSGIATGS HSSYSSSLSS YAGSSLDVWR ATDELGSLLS LPAAGAPEPS LCTCLPGTVE YQVPTSLRAH YDTPRSLCLA PRDHSPPSQG SPGNSAARDS GGQTSAGCPS GWLGTRRRGL VMEAPQDSEA TLPGPAPGEP WEAGGPHAGP PPAFFSACPV CGGLKVNPPP (136-504 aa encoded by BC131544)
靶标信息
The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Downstream of tyrosine kinase 7; Protein Dok-7
基因别名: C4orf25; CMS10; CMS1B; DOK7
UniProt ID: (Human) Q18PE1
Entrez Gene ID: (Human) 285489
