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Invitrogen

DRD1 Polyclonal Antibody

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查看其他32个DRD1抗体

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产品信息

PA5-27172

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:3,000
查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:100-1:1,000
-

免疫组化（冰冻） (IHC (F))

1:100-1:1,000
-

免疫细胞化学 (ICC/IF)

1:100-1:1,000
-
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide encompassing a sequence within the Intracellular domain of human Dopamine Receptor D1. The exact sequence is proprietary.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.46 mg/mL

规格

146 µg

纯化类型

Protein A

保存液

PBS, pH 7, with 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2544648

产品详细信息

Recommended positive controls: IMR32.

Predicted reactivity: Rhesus Monkey (100%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: D(1A) dopamine receptor; D1 receptor; D1A dopamine receptor; D1a receptor; Dopamine 1 receptor; Dopamine D1 receptor; dopamine receptor D1A; Dopamine-1A receptor; DRD1; G protein-coupled receptor DRD1; G-protein coupled receptor; unnamed protein product

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基因别名: C030036C15Rik; D1a; D1R; DADR; Drd-1; DRD1; DRD1A; Gpcr15

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UniProt ID: (Mouse) Q61616

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Entrez Gene ID: (Human) 1812, (Mouse) 13488, (Rat) 24316

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功能
dopamine neurotransmitter receptor activity, coupled via Gs G-protein alpha-subunit binding G-protein coupled receptor activity dopamine neurotransmitter receptor activity protein binding heterotrimeric G-protein binding dopamine binding arrestin family protein binding signal transducer activity receptor binding drug binding G-protein coupled amine receptor activity protein phosphatase binding angiotensin receptor binding D3 dopamine receptor binding protein complex binding protein heterodimerization activity ATPase binding G-protein coupled receptor
参与通路
synaptic transmission, dopaminergic G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway dopamine receptor signaling pathway synapse assembly learning memory mating behavior locomotory behavior adult walking behavior associative learning visual learning response to xenobiotic stimulus transmission of nerve impulse cerebral cortex GABAergic interneuron migration positive regulation of cell migration vasodilation dopamine metabolic process positive regulation of potassium ion transport positive regulation of MAPK cascade regulation of synaptic plasticity positive regulation of release of sequestered calcium ion into cytosol regulation of dopamine uptake involved in synaptic transmission positive regulation of synaptic transmission, glutamatergic phospholipase C-activating dopamine receptor signaling pathway cellular response to catecholamine stimulus adenylate cyclase-activating adrenergic receptor signaling pathway modification of postsynaptic structure presynaptic modulation of chemical synaptic transmission negative regulation of behavioral fear response temperature homeostasis conditioned taste aversion behavioral fear response startle response response to amphetamine negative regulation of protein kinase activity protein import into nucleus intracellular protein transport muscle contraction signal transduction activation of adenylate cyclase activity chemical synaptic transmission sensory perception of chemical stimulus grooming behavior feeding behavior positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway astrocyte development dopamine transport neuronal action potential regulation of vasoconstriction calcium-mediated signaling dentate gyrus development striatum development hippocampus development negative regulation of cell migration peristalsis positive regulation of cAMP biosynthetic process phosphatidylinositol catabolic process operant conditioning social behavior regulation of dopamine metabolic process response to cocaine negative regulation of circadian sleep/wake cycle, sleep response to drug maternal behavior regulation of ion transport positive regulation of adenylate cyclase activity positive regulation of membrane potential glucose import phosphatidylinositol metabolic process habituation sensitization behavioral response to cocaine regulation of long-term neuronal synaptic plasticity positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway prepulse inhibition long-term synaptic potentiation long term synaptic depression positive regulation of long-term synaptic potentiation positive regulation of feeding behavior response to organonitrogen compound response to organic cyclic compound response to activity orbitofrontal cortex development response to food response to estradiol response to retinoic acid cellular response to insulin stimulus response to nicotine response to antidepressant response to amino acid response to morphine response to ethanol response to steroid hormone cellular response to hypoxia
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