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Proteintech
DTX3L Polyclonal Antibody
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产品信息
11963-1-AP
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
DTX3L Fusion Protein Ag2568 (430-741 aa encoded by BC060509)
偶联物
形式
Liquid
浓度
0.33 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: SVHAYASFI DAFQHASCQL MREVLLLKSL GKERKHLHQT KFADDFRKRH PNVHFVLNQE SMTLTGLPNH LAKAKQYVLK GGGMSSLAGK KLKEGHETPM DIDSDDSKAA SPPLKGSVSS EASELDKKEK GICVICMDTI SNKKVLPKCK HEFCAPCINK AMSYKPICPT CQTSYGIQKG NQPEGSMVFT VSRDSLPGYE SFGTIVITYS MKAGIQTEEH PNPGKRYPGI QRTAYLPDNK EGRKVLKLLY RAFDQKLIFT VGYSRVLGVS DVITWNDIHH KTSRFGGPEM YGYPDPSYLK RVKEELKAKG IE (430-741 aa encoded by BC060509)
靶标信息
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: B-lymphoma- and BAL-associated protein; deltex 3 like, E3 ubiquitin ligase; deltex 3-like; E3 ubiquitin-protein ligase DTX3L; Protein deltex-3-like; rhysin 2; Rhysin-2; Rhysin2; RING-type E3 ubiquitin transferase DTX3L
基因别名: BBAP; DTX3L
UniProt ID: (Human) Q8TDB6
Entrez Gene ID: (Human) 151636
