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Proteintech
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Immunogen sequence: MAARRGALI VLEGVDRAGK STQSRKLVEA LCAAGHRAEL LRFPERSTEI GKLLSSYLQK KSDVEDHSVH LLFSANRWEQ VPLIKEKLSQ GVTLVVDRYA FSGVAFTGAK ENFSLDWCKQ PDVGLPKPDL VLFLQLQLAD AAKRGAFGHE RYENGAFQER ALRCFHQLMK DTTLNWKMVD ASKSIEAVHE DIRVLSEDAI RTATEKPLGE LWK (1-212 aa encoded by BC001827)
Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway for DNA synthesis. DTYMK is essential for DNA synthesis and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs, including 5-Fluorouracil (5-FU), the chemotherapeutic drug of choice for several solid tumors. The human DTYMK gene was isolated via functional complementation of a Saccharomyces cerevisiae cell cycle mutant, cdc8. DTYMK mRNA levels and enzyme activities are regulated at the level of cell cycle and cell growth pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: deoxythymidylate kinase (thymidylate kinase); dTMP kinase; Thymidylate kinase
基因别名: AU044245; CDC8; D10Ertd203e; DTYMK; mtmk; PP3731; Tmk; TMPK; TYMK; TYPK
UniProt ID: (Human) P23919, (Mouse) P97930
Entrez Gene ID: (Human) 1841, (Mouse) 21915