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Invitrogen
DUOX1 Polyclonal Antibody
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产品信息
PA5-54817
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: QHKEELTWED FHFMLRDHNS ELRFTQLCVK GVEVPEVIKD LCRRASYISQ DMICPSPRVS ARCSRSDIET ELTPQRLQCP MDTDPPQEIR RRFGKKVTSF QP
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 83%.
靶标信息
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX2. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dual oxidase 1; flavoprotein NADPH oxidase; Large NOX 1; Long NOX 1; NADPH thyroid oxidase 1; nicotinamide adenine dinucleotide phosphate oxidase; Thyroid oxidase 1
基因别名: DUOX; DUOX1; LNOX1; NOXEF1; THOX1
UniProt ID: (Human) Q9NRD9
Entrez Gene ID: (Human) 53905
thyroid hormone generation
response to oxidative stress
cytokine-mediated signaling pathway
cuticle development
hormone biosynthetic process
superoxide anion generation
hydrogen peroxide catabolic process
hydrogen peroxide biosynthetic process
response to cAMP
oxidation-reduction process
cellular oxidant detoxification
