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Proteintech
DYNC1H1 Polyclonal Antibody, CoraLite® Plus 488
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产品信息
CL488-12345
产品规格
种属反应
Human,
Mouse,
Rat,
Zebrafish
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
PBS with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: MAQSIYGGRV DNEFDQRLLN TFLERLFTTR SFDSEFKLAC KVDGHKDIQM PDGIRREEFV QWVELLPDTQ TPSWLGLPNN AERVLLTTQG VDMISKMLKM QMLEDEDDLA YAETEKKTRT DSTSDGRPAW MRTLHTTASN WLHLIPQTLS HLKRTVENIK DPLFRFFERE VKMGAKLLQD VRQDLADVVQ VCEGKKKQTN YLRTLINELV KGILPRSWSH YTVPAGMTVI QWVSDFSERI KQLQNISLAA ASGGAKELKN IHVCLGGLFV PEAYITATRQ YVAQANSWSL EELCLEVNVT TSQGATLDAC SFGVTGLKLQ GATCNNNKLS LSNAISTALP LTQLRWVKQT NTEKKASVVT LPVYLNFTRA DLIFTVDFEI ATKEDPRSFY ERGVAVLCTE
靶标信息
DYNC1H1 (Dynein Cytoplasmic 1 Heavy Chain 1) is a gene that encodes a protein belonging to the dynein family, which are motor proteins critical for various cellular processes. Dyneins are responsible for retrograde intracellular transport along microtubules, meaning they move cargo from the periphery of the cell towards the nucleus. The DYNC1H1 protein is a heavy chain component of cytoplasmic dynein 1, which plays a key role in the movement of organelles, vesicles, and other cellular components. Mutations in DYNC1H1 have been associated with several neurological disorders, including spinal muscular atrophy with lower extremity predominance (SMA-LED) and Charcot-Marie-Tooth disease type 2O (CMT2O). Research into DYNC1H1 continues to uncover its involvement in cellular mechanics and its implications in various genetic conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein heavy chain 1; cytoplasmic dynein heavy chain polypeptide 1; Dynein heavy chain, cytosolic; dynein heavy chain, retrograde transport; dynein, cytoplasmic 1, heavy chain 1; dynein, cytoplasmic, heavy chain 1; dynein, cytoplasmic, heavy polypeptide 1; legs at odd angle; MAP 1C; sprawling
基因别名: 9930018I23Rik; AI894280; CMT2O; DHC1; DHC1a; DNCH1; Dnchc1; DNCL; Dnec1; DNECL; DYHC; DYNC1H1; fk70a07; HL-3; KIAA0325; Loa; MAP1C; mKIAA0325; P22; SMALED1; Swl; wu:fk70a07
UniProt ID: (Human) Q14204, (Rat) P38650, (Mouse) Q9JHU4
Entrez Gene ID: (Human) 1778, (Rat) 29489, (Mouse) 13424, (Zebrafish) 335110
G2/M transition of mitotic cell cycle
ER to Golgi vesicle-mediated transport
microtubule-based movement
mitotic spindle organization
antigen processing and presentation of exogenous peptide antigen via MHC class II
cytoplasmic mRNA processing body assembly
stress granule assembly
establishment of spindle localization
transport
biological_process
metabolic process
cilium movement
central nervous system myelination
myelination
camera-type eye photoreceptor cell differentiation
