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Abnova
DYNC1H1 Polyclonal Antibody, MaxPab™
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产品信息
H00001778-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
DYNC1H1 (AAH64521.1, 1 a.a. approximately 197 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MISKMLKMQM LEDEDDLAYA ETEKKTRTDS TSDGRPAWMR TLHTTASNWL HLIPQTLSHL KRTVENIKDP LFRFFEREVK MGAKLLQDVR QDLADVVQVC EGKKKQTNYL RTLINELVKG ILPRSWSHYT VPAGMTVIQW VSDFSERIKQ LQNISLAAAS GGAKELKVKA LLTSLGWSAA VLGWGGSGSG EKHRAQV
靶标信息
DYNC1H1 (Dynein Cytoplasmic 1 Heavy Chain 1) is a gene that encodes a protein belonging to the dynein family, which are motor proteins critical for various cellular processes. Dyneins are responsible for retrograde intracellular transport along microtubules, meaning they move cargo from the periphery of the cell towards the nucleus. The DYNC1H1 protein is a heavy chain component of cytoplasmic dynein 1, which plays a key role in the movement of organelles, vesicles, and other cellular components. Mutations in DYNC1H1 have been associated with several neurological disorders, including spinal muscular atrophy with lower extremity predominance (SMA-LED) and Charcot-Marie-Tooth disease type 2O (CMT2O). Research into DYNC1H1 continues to uncover its involvement in cellular mechanics and its implications in various genetic conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein heavy chain 1; Dynein heavy chain, cytosolic; dynein, cytoplasmic 1, heavy chain 1; dynein, cytoplasmic, heavy polypeptide 1
基因别名: CMT2O; DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; DYNC1H1; HL-3; KIAA0325; p22; SMALED1
UniProt ID: (Human) Q14204
Entrez Gene ID: (Human) 1778
G2/M transition of mitotic cell cycle
ER to Golgi vesicle-mediated transport
microtubule-based movement
mitotic spindle organization
antigen processing and presentation of exogenous peptide antigen via MHC class II
cytoplasmic mRNA processing body assembly
stress granule assembly
establishment of spindle localization
