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Proteintech
Decorin Polyclonal Antibody
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产品信息
14667-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Hamster,
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Decorin Fusion Protein Ag6328 (1-359 aa encoded by BC005322)
偶联物
形式
Liquid
浓度
0.18 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MKATIILLL LAQVSWAGPF QQRGLFDFML EDEASGIGPE VPDDRDFEPS LGPVCPFRCQ CHLRVVQCSD LGLDKVPKDL PPDTTLLDLQ NNKITEIKDG DFKNLKNLHA LILVNNKISK VSPGAFTPLV KLERLYLSKN QLKELPEKMP KTLQELRAHE NEITKVRKVT FNGLNQMIVI ELGTNPLKSS GIENGAFQGM KKLSYIRIAD TNITSIPQGL PPSLTELHLD GNKISRVDAA SLKGLNNLAK LGLSFNSISA VDNGSLANTP HLRELHLDNN KLTRVPGGLA EHKYIQVVYL HNNNISVVGS SDFCPPGHNT KKASYSGVSL FSNPVQYWEI QPSTFRCVYV RSAIQLGNYK (1-359 aa encoded by BC005322)
靶标信息
Decorin is a member of the small, leucine-rich proteoglycan (SLRP) family along with biglycan. Found in the interterritorial region of cartilage, decorin interacts with collagen and other matrix proteins to regulate the cartilaginous matrix. It has been shown to interact with fibronectin, thrombospondin, C1q, epidermal growth factor receptor (EGFR), and TGF-b. It is believed that decorin also plays a role in the cell cycle of chondrocytes. The decorin neoepitope fragment has a sequence of PKTLQE, and is generated by MMP-3 or ADAMTS-4 cleavage at Glu154-Leu155 of decorin core protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Bone proteoglycan II; Decorin; Dermatan sulfate proteoglycan-II; dermatan sulfate proteoglycan-II (decorin); dermatan sulphate proteoglycans II; Dermatan sulphate proteoglycans II (DSPG2); DSPG; PG-S2; PG40; proteoglycan core protein; Small leucine rich protein 1B; small leucine-rich protein 1B
基因别名: CSCD; DC; DCN; DSPG2; mDcn; PG40; PGII; PGS2; SLRR1B
UniProt ID: (Human) P07585, (Mouse) P28654, (Rat) Q01129
Entrez Gene ID: (Human) 1634, (Mouse) 13179, (Rat) 29139
positive regulation of autophagy
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
kidney development
placenta development
skeletal muscle tissue development
aging
response to mechanical stimulus
response to lipopolysaccharide
wound healing
negative regulation of protein kinase activity
organ morphogenesis
negative regulation of endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of macroautophagy
negative regulation of angiogenesis
cytokine-mediated signaling pathway
extracellular matrix disassembly
extracellular matrix organization
glycosaminoglycan metabolic process
chondroitin sulfate biosynthetic process
chondroitin sulfate catabolic process
dermatan sulfate biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JAK-STAT cascade
positive regulation of mitochondrial depolarization
positive regulation of mitochondrial fission
negative regulation of vascular endothelial growth factor signaling pathway
