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Proteintech
Desmoplakin Polyclonal Antibody
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产品信息
25318-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Desmoplakin Fusion Protein Ag18065 (1-350 aa encoded by BC140802)
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody detects both DP1 (280-330 kDa) and DP2 (240-260 kDa).
Immunogen sequence: MSCNGGSHP RINTLGRMIR AESGPDLRYE VTSGGGGTSR MYYSRRGVIT DQNSDGYCQT GTMSRHQNQN TIQELLQNCS DCLMRAELIV QPELKYGDGI QLTRSRELDE CFAQANDQME ILDSLIREMR QMGQPCDAYQ KRLLQLQEQM RALYKAISVP RVRRASSKGG GGYTCQSGSG WDEFTKHVTS ECLGWMRQQR AEMDMVAWGV DLASVEQHIN SHRGIHNSIG DYRWQLDKIK ADLREKSAIY QLEEEYENLL KASFERMDHL RQLQNIIQAT SREIMWINDC EEEELLYDWS DKNTNIAQKQ EAFSIRMSQL EVKEKELNKL KQESDQLVLN QHPASDKIEA Y (1-350 aa encoded by BC140802)
靶标信息
Desmoplakin (DSP) is a major high molecular weight protein of the desmosomes. It is involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Desmoplakin mutations are associated with Keratoderma and cardiomyopathy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 250/210 kDa paraneoplastic pemphigus antigen; Desmoplakin; desmoplakin I/II; Desmoplakin II; Desmoplakin-I; desmosomal cytoskeletal connector molecule; DP
基因别名: 2300002E22Rik; 5730453H04Rik; AA407887; AA407888; AW109828; DCWHKTA; DP; DSP; rul
UniProt ID: (Human) P15924, (Mouse) E9Q557
Entrez Gene ID: (Human) 1832, (Mouse) 109620
protein kinase C binding
structural molecule activity
structural constituent of cytoskeleton
protein binding
protein binding, bridging
poly(A) RNA binding
cell adhesion molecule binding
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
scaffold protein binding
intermediate filament binding protein
desmosome organization
ventricular compact myocardium morphogenesis
epidermis development
peptide cross-linking
keratinocyte differentiation
adherens junction organization
wound healing
intermediate filament organization
protein localization to adherens junction
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
regulation of ventricular cardiac muscle cell action potential
single organismal cell-cell adhesion
skin development
intermediate filament cytoskeleton organization
