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Invitrogen
Diphtheria Toxin A Monoclonal Antibody (7F2)
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产品信息
MA1-46399
产品规格
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
7F2
抗原
Full length Diphtheria toxin A-subunit protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
8.6 mg/mL
规格
100 µg
保存条件
4°C, do not freeze
运输条件
Wet ice
RRID
产品详细信息
This antibody reacts with the epitope exposed on the free A subunit and on the whole Diphtheria toxin molecule, and does not react with the free B subunit of Diphtheria toxin.
靶标信息
Diphtheria toxin is a 58 kDa protein secreted by lysogenic strains of Corynebacterium diphtheriae. The toxin causes the disease diphtheria in humans by gaining entry into the cell cytoplasm and inhibiting protein synthesis. The mechanism of inhibition involves transfer of the ADP-ribose group of NAD to elongation factor-2 (EF-2), rendering EF-2 inactive. The catalysed reaction is as follows: NAD + + peptide diphthamide = nicotinamide + peptide N-(ADP-D-ribosyl)diphthamide The crystal structure of the diphtheria toxin homodimer has been determined to 2.5A resolution. The structure reveals a Y-shaped molecule of 3 domains, a catalytic domain (fragment A), whose fold is of the alpha + beta type; a transmembrane (TM) domain, which consists of 9 alpha-helices, 2 pairs of which may participate in pH-triggered membrane insertion and translocation; and a receptor-binding domain, which forms a flattened beta-barrel with a jelly-roll-like topology. The TM- and receptor binding-domains together constitute fragment B.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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