Progen

Drebrin Monoclonal Antibody (MX823)

Name: Drebrin Monoclonal Antibody (MX823)
Brand: Progen
SKU: 651128PROGEN

查看其他23个Drebrin抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

产品信息

651128PROGEN

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:100

免疫组化（冰冻） (IHC (F))

1:10-1:50

免疫细胞化学 (ICC/IF)

Assay-dependent

免疫沉淀 (IP)

Assay-dependent

产品规格

种属反应

Bovine, Dog, Human, Mouse, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

MX823

抗原

Synthetic C-Terminal Peptide (Aa 632-649) Coupled To Klh

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

Conc. Not Determined

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

MX823 specifically reacts with drebrin, a widespread actin-associating protein of 70 kD (SDS-PAGE mobility shows MW 120,000). It is enriched at junctional plaques, defining a specific microfilament anchorage system in polar epithelial cells. Positive staining was found in many tissues, including diverse epithelia and carcinoma (e.g. in epidermis basal cells are positive, whereas overlying cells are negative; also positive: regenerating epithelium during wound healing; basal cell carcinoma; skin melanoma), specific types of endothelia and smooth muscle; especially prominent in the mesangial cells of renal glomeruli and in the Sertoli cells of testis. Also positive: epithelia of hair follicles and eccrine sweat glands. Consistently negative were, however, hepatocytes and cross-striated muscle.Reactivity on Cultured cell lines: Primary human keratinocytes, U333, MCF-7, SV80; B16 (mouse melanoma cells).

靶标信息

The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。